The United Kingdom’s Brexit Secretary, Dominic Raab, and the Secretary of State for Work and Pensions, Esther McVey, have resigned along with two junior ministers over the draft European Union (EU) withdrawal agreement.

The move comes as a huge blow to British Prime Minister Theresa May. Raab was appointed the Brexit secretary only in July after David Davis resigned in protest against “a business-friendly” deal to leave the EU.

“I regret to say that, following the Cabinet meeting yesterday on the Brexit deal, I must resign,” Raab said. May’s plan threatened the integrity of the UK, he said.

The British prime minister secured the uneasy support of her cabinet for the draft deal with Brussels after a stormy five-hour meeting on Wednesday night.

Consensus only lasted a matter of hours before the resignations, as speculation is mounting that angry Tory lawmakers are preparing to launch a bid to topple the prime minister.